Genome‑wide CRISPR screens in primary human T cells reveal human genes that promote or block HIV infection, uncovering potent ...

A research team has discovered an enhanced CRISPR gene-editing system that could enable targeted delivery inside the human ...

The human immunodeficiency virus (HIV), which is the cause of AIDS, is a master of deception, using just nine genes to hijack ...

For the millions of people living with genetic diseases like muscular dystrophy and inherited liver disorders, one of the ...

The last time The Lancet Microbe featured an Editorial on CRISPR was in November 2020, to mark that year’s Nobel Prize in Chemistry, jointly awarded to Emmanuelle Charpentier and Jennifer A Doudna for ...

A compact Cas12f nuclease shows high editing efficiency in human cells, with structural insights enabling an engineered variant potentially suited for future AAV‑compatible delivery.

When CRISPR cuts a gene flanked by short, repeating DNA sequences, the cell’s repair machinery gets confused. It simply zips ...

The rapid evolution of CRISPR/Cas genome editing has redefined the possibilities of cellular and gene therapy, enabling ...

If CRISPR stays active too long, it could cut unintended parts of the genome. To reduce this risk, the researchers designed a self-inactivating CRISPR system. This means that CRISPR edits the gene and ...

Cas12a platform for rapid and visual detection of Epizootic Hemorrhagic Disease Virus (EHDV), enabling on-site diagnosis within 1 h without specialized equipment.

These horses might look like ordinary horses, but there is something highly unusual about their genomes. They are the first of their species to have their DNA edited using CRISPR–Cas9, a technique ...